BSASM is the active compound of the finished products for Atopic Dermatitis. It can be used 2~3% as the final concentration in the finished product.

(The technical sheet)

(The technical sheet will be sent together with at least 1 unit of product )

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(In the technical sheet)
Summary

BSASM™ is a multi-herbal preparation that is composed of several plant extracts such as Rosemarinus officinalis, Matricaria recubita, Camellia sinensis, Glycyrrhiza glabra, Polygonum cuspidatum, Scutellaria baicalensis , and Centella asiatica .It has multiple functions such as antioxidant, anti-inflammatory, and immunomodulatory effects . It can be introduced as a main ingredient in cosmeceuticals for skin diseases; acne, atopic dermatitis, seborrhea, or psoriasis. It induces no adverse effects such as eczema, pruritus, redness and so on when applied to human skin. It is an optimum synergistic combination of botanical fractions of the following herbs.

Atopic dermatitis (AD) is a common chronic inflammatory skin disease, occurring most commonly during early infancy and childhood, characterized by a chronically relapsing course. Although the pathogenesis of AD is not fully understood, it has been reported that AD is associated with multiple immunologic abnormalities. The most prominent findings of immune dysfunction are the high level of immunoglobulin E (IgE) in peripheral blood and increased IgE production by B cells. In AD, Th2 cells are mainly activated and then secret IL-4, IL-5 and IL-10.

Symptoms of AD induced by these signal transduction pathway mostly accompany inflamed skin damage as well as skin dryness. Accordingly, the generally accepted prescription includes moisturizers and topical steroids that maintain a level of moisture in the skin and suppress inflammatory reaction, respectively. However, when topically treated for a long time, steroid hormone has been known to induce adverse side effects. In addition, cyclosporin A and FK506 which are used as a non-steroid therapeutic agent have been reported to induce cutaneous T cell lymphoma, fever, extreme rises in serum alkaline phosphatase in children, enhanced irritation and relapsing Kaposi's varicelliform eruption and so on.

Therefore, at present, many researches are actively trying to develop therapeutic agents which have high anti-inflammatory effect with the least side effects. To this end, as a first step, we selected chemicals which were known to be involved in anti-inflammatory and antioxidant mechanisms and then using these chemicals, we prepared a variety of formulations. Subsequently, we screened candidate formulation which has high anti-inflammatory effect using an NF-kB luciferase reporter. In the course of this screening, we obtained BSASM preparation, a mixture of 7 herbal extracts.