Anti-Aging, Skin Soothing
Liposomized anti-wrinkle ingredient registered by KFDA
Multi-layered liposome containing 5% Asiaticoside extracted from Centella asiatica
Ingredient with multi-layered liposome delivered to the deep skin
Improves collagen production and cell proliferation
 >> INCI Name & the Plant Source
 >> Claims on FMLT GotuSphere 5.0™
 >> Asiaticoside is the Main Active Ingredient of FMLT GotuSphere 5.0™
 >> Physical Properties of FMLT GotuSphere 5.0™
 >> Solubility of FMLT GotuSphere 5.0™
 >> Stability of Asiaticoside
 >> Re-densifing Effects of Asiaticoside
 >> Clinical Tests on FMLT GotuSphere 5.0™
 >> Publications on FMLT GotuSphere 5.0™
>> INCI Name & the Plant Source
INCI Name: Asiaticoside
Plant Source: Gotu kola (Centella asiatica)
>> Claims on FMLT GotuSphere 5.0™
Multi-layered liposome containing 5% of asiaticoside
Effective ingredient for cosmeceuticals for skin problems due to skin aging
Stable and effective over the pH range typically found in personal care products
Possess average thermal stability
An active anti-aging ingredient
Scientific data is published in the Planta Medica and International Journal of Cosmetic Science
>> Asiaticoside is the Main Active Ingredient of FMLT GotuSphere 5.0™
Centella asiatica (Gotu kola) is a small perennial herbaceous plant which has been used for many years in Europe for wound healing. Centella asiatica contains vallejin, a bitter principal, and a mixture of triterpenoid glycosides ? the most abundant being asiaticosides and madecassosides. These triterpenes act on fibroblast cells to restore elastic connective tissue, reduce fibrosis and shorten the time required for wound healing. Overall actions result increase in the tensile strength of the tissues and the improvement of its natural defense.
>> Physical Properties of FMLT GotuSphere 5.0™
>> Solubility of FMLT GotuSphere 5.0™
>> Stability of Asiaticoside
Stability of asiaticoside in final product, lotion, is stable for 12 months in all conditions tested
>> Re-densifing Effects of Asiaticoside
Asiaticoside shows re-densifing effects by ①proliferating human dermal fibroblasts, ②supplementing additional collagen to dermal cells, and ③inhibiting collagen degration. These results make the Asiaticoside as the effective anti-aging ingredient.
>> Clinical Tests on FMLT GotuSphere 5.0™
FMLT GotuSphere 5.0TM was applied to the volunteers for 12 consecutive weeks. As expected, the skin texture and cell density was improved dramatically in volunteers treated with FMLT GotuSphere 5.0TM with no skin irritation. FMLT GotuSphere 5.0TM is the natural active ingredient with potent anti-aging effects.
>> Publications on FMLT GotuSphere 5.0™
Scientific analysis on in vitro and in vivo action mechanism is published in Planta Medica (2006) and International Journal of Cosmetic Science (2008).
Lee, J. et al., Asiaticoside Induces Human Collagen I Synthesis through TGFbeta Receptor I Kinase-Independent Smad Signaling, Planta Medica, 2006(72):324-328
Lee, J. et al., Evaluation of the effects of a preparation containing asiaticoside on periocular wrinkles of human volunteers, International Journal of Cosmetic Science, 2008(30):167-173
Cosmetic composition for reducing skin wrinkles comprising asiaticoside
Registration No.:10-0641302-0000; Registration Date: Oct 25, 2006
Korean application No.: KR10-2005-0051604/Filing Date: Jul 15, 2005