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In vitro claims Substantiation & Toxicology Testing Services

Client testing and research form an important part of our business. We offer an extensive range of cell-based and biochemical claims support and toxicological testing systems. Although many of these systems are off-the-shelf tests that are "tried and true" indicators of efficacy, most can be modified as necessary to suit a client's particular needs. Our claims substantiation experts take pride in their ability to assist clients in designing and executing customized or altogether new assays that specifically target novel endpoints. These services provide our clients with the added advantage of innovative product development programs.

BioSpectrum's in vitro testing services cover the entire range, from the routine assay of research materials and production samples in strict compliance with client specifications, to ground-up custom assay development and validation. We welcome client oversight because active client participation is key to successful contract research. All client work is fully reported in a timely fashion, including interpretation and new approaches for future evaluation.

Major areas addressed by our in vitro testing services are:

     
  Inflammation  
   Cytokine/eicosanoid generation   
   Transendothelial chemotaxis  
   ECM degradation  
   COX assay  
     
  Structural Proteins  
   Collagen production 
 
   Collagenase activity   
   Elastase activity   
   Keratin type expression  
     
  Antioxidant Activity  
   Free radical scavenging  
   Respiratory burst measurement  
   Lipid damage  
     
  Melanogenesis  
    Tyrosinase inhibition  
   Melanocyte whitening/tanning  
   Epidermal equivalent screening  
     
     
     
  Cellular metabolism  
   Cell proliferation  
   Mitochondrial integrity  
   Glucose metabolism  
   Lipid metabolism   
     
  Cytotoxicity  
   Neutral Red uptake/release  
 
   MTT metabolism    
   Ocular & Dermal Irritection¢ç testing    
   Corrosivity testing (packing group   designation)  
     
  UV studies  
   Cell-based photoprotection/ phototoxicity  
   Cellular inflammatory responses to UV  
   Lipid peroxidation  
   UV blockage  
     
  Custom Assay Development  
    Cell-based & biochemical tests  
    ELISA & Western blot detection systems  
     

¢º Contact to : esjung@biospectrum.com

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